Screenshots released today of Harley Quinn from Lego Batman: The Videogame, which means this is probably what the actual minifig will look like in a kit released later on this year. I like the head, but I still think my torso design is better. 
More screenshots at Shacknews.
On a related note, I love Paul Dini’s current writing on Detective Comics. More Harley and Zatanna (in April)!
The head is pretty good, but I for one will continue to treasure my custom Harley minifig. She has more attitude.